Amoxicillin and Metronidazole as an Adjunct to Full-Mouth Scaling?
Methods: Fifty-one patients received full-mouth periodontal debridement, performed within 48 hours. Twenty-five subjects received metronidazole, 500 mg, and amoxicillin, 375 mg, three times a day for 7 days; 26 subjects received a placebo.
Results: Mean probing depth decreased from 4.3 ± 0.4 mm to 3.0 ± 0.2 mm in the test group and from 4.4 ± 0.4 mm to 3.1 ± 0.3 mm in the control group. Test subjects had a significantly lower mean number of persisting pockets >4 mm and bleeding on probing that required further treatment.
Conclusions: Systemic metronidazole and amoxicillin significantly improved the 6-month clinical outcomes of full-mouth non-surgical periodontal debridement. There was a significant reduction in the need for additional therapy.
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Journal of PeriodontologyVolume 80, Issue 3. 01 March 2009
Amoxicillin and Metronidazole as an Adjunct to Full-Mouth Scaling and Root Planing of Chronic Periodontitis
Norbert Cionca, Catherine Giannopoulou, Giovanni Ugolotti, Andrea Mombelli