Amoxicillin and Metronidazole as an Adjunct to Full-Mouth Scaling?

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Methods: Fifty-one patients received full-mouth periodontal debridement, performed within 48 hours. Twenty-five subjects received metronidazole, 500 mg, and amoxicillin, 375 mg, three times a day for 7 days; 26 subjects received a placebo. 

Results: Mean probing depth decreased from 4.3 ± 0.4 mm to 3.0 ± 0.2 mm in the test group and from 4.4 ± 0.4 mm to 3.1 ± 0.3 mm in the control group. Test subjects had a significantly lower mean number of persisting pockets >4 mm and bleeding on probing that required further treatment. 

Conclusions: Systemic metronidazole and amoxicillin significantly improved the 6-month clinical outcomes of full-mouth non-surgical periodontal debridement. There was a significant reduction in the need for additional therapy. 

For more information please refer to: 

Journal of PeriodontologyVolume 80, Issue 3.  01 March 2009 

Amoxicillin and Metronidazole as an Adjunct to Full-Mouth Scaling and Root Planing of Chronic Periodontitis 

Norbert Cionca, Catherine Giannopoulou, Giovanni Ugolotti, Andrea Mombelli

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